{"id":5870,"date":"2026-07-20T10:56:18","date_gmt":"2026-07-20T10:56:18","guid":{"rendered":"https:\/\/tarumi.co.jp\/blog\/?p=5870"},"modified":"2026-07-20T11:00:42","modified_gmt":"2026-07-20T11:00:42","slug":"%e6%96%b0%e3%81%97%e3%81%84%e7%b7%91%e5%86%85%e9%9a%9c%e8%96%ac%e3%81%8c%e5%87%ba%e3%82%8b%e3%82%89%e3%81%97%e3%81%84%e3%81%a7%e3%81%99%e3%80%82","status":"publish","type":"post","link":"https:\/\/tarumi.co.jp\/blog\/?p=5870","title":{"rendered":"\u65b0\u3057\u3044\u7dd1\u5185\u969c\u85ac\u304c\u51fa\u308b\u3089\u3057\u3044\u3067\u3059\u3002"},"content":{"rendered":"<p><a href=\"https:\/\/tarumi.co.jp\/blog\/?p=5490\">\u30bb\u30bf\u30cd\u30aa<\/a>\u306b\u7d9a\u304d\u3001\u65b0\u3057\u3044\u7dd1\u5185\u969c\u85ac\u304c\u767a\u58f2\u3055\u308c\u308b\u4e88\u5b9a\u3067\u3059\u3002<br \/>\n\u300c\u307e\u3060\u672a\u767a\u8868\u3067\u3059\u300d\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u304c<a href=\"https:\/\/medical.nikkeibp.co.jp\/leaf\/all\/series\/drug\/update\/202607\/593910.html\">\u65e5\u7d4c\u30e1\u30c7\u30a3\u30ab\u30eb<\/a>\u306b\u8f09\u3063\u3066\u307e\u3057\u305f\u3002<\/p>\n<p>\u3088\u308b\u3068\u3001\u65b0\u85ac\u306e\u540d\u524d\u306f<b>\u30ed\u30fc\u30d7\u30ec\u30c3\u30b5<\/b>\u70b9\u773c\u6db20.02\uff05\u3067\u3001\u6210\u5206\u306f<strong>\u30cd\u30bf\u30eb\u30b9\u30b8\u30eb<\/strong>\u30e1\u30b7\u30eb\u9178\u5869\u3067\u3059\u3002<\/p>\n<ol>\n<li><strong>\u30ea\u30d0\u30b9\u30b8\u30eb\uff08\u30b0\u30e9\u30ca\u30c6\u30c3\u30af\uff09\u3068\u306e\u5171\u901a\u70b9<\/strong>\n<ul>\n<li>Rho\u30ad\u30ca\u30fc\u30bc\uff08ROCK\uff09\u963b\u5bb3\u306b\u3088\u3063\u3066\u623f\u6c34\u6d41\u51fa\u3092\u4fc3\u9032<\/li>\n<\/ul>\n<\/li>\n<li><strong>\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u30fb\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc\uff08NET\uff09\u3078\u306e\u4f5c\u7528<\/strong>\n<ul>\n<li>\u623f\u6c34\u7523\u751f\u3092\u6291\u5236<\/li>\n<\/ul>\n<\/li>\n<\/ol>\n<p>\u623f\u6c34\u6d41\u51fa\u2191\uff0b\u623f\u6c34\u7523\u751f\u2193 \u2192 \u30b0\u30e9\u30ca\u30c6\u30c3\u30af\u3088\u308a\u52b9\u3044\u3066\u3001\u4e00\u65e5\u4e00\u56de\u306e\u70b9\u773c\u3067OK<\/p>\n<p>\uff12\u306eNET(\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u30c8\u30e9\u30f3\u30b9\u30dd\u30fc\u30bf\u30fc)\u963b\u5bb3\u85ac\u306f\u3001\u30ce\u30eb\u30a8\u30d4\u30cd\u30d5\u30ea\u30f3\u306e\u518d\u5438\u53ce\u3092\u6291\u3048\u308b\u3002<br \/>\n\u304b\u3064\u3066\u5b58\u5728\u3057\u305f\u30d4\u30d0\u30ec\u30d5\u30ea\u30f3\u3068\u540c\u69d8\u306e\u4ea4\u611f\u795e\u7d4c\u4f5c\u52d5\u85ac\u3060\u304c\u3001\u518d\u5438\u53ce\u6291\u5236\u3068\u3044\u3046\u70b9\u304c\u7570\u306a\u308b\u3002<br \/>\n\u4ea4\u611f\u795e\u7d4c\u4f5c\u52d5\u306b\u3088\u308a\u3001\u7dd1\u5185\u969c\u85ac\u306e\u5145\u8840\u3092\u6291\u5236\u3059\u308b\u304b\u3068\u3044\u3046\u3068\u3001\u3055\u306b\u3042\u3089\u305a\u3067\u3001\u5145\u8840\u767a\u751f\u7387\u306f\uff15\uff10\uff05\u306b\u53ca\u3076\u3089\u3057\u3044\u3002<\/p>\n<p><strong class=\"Yjhzub\" data-sfc-root=\"ep\" data-sfc-cb=\"\" data-complete=\"true\" data-copy-service-computed-style=\"font-family: &quot;Google Sans&quot;, Arial, sans-serif; font-size: 16px; font-weight: 700; margin: 0px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);\"><span data-subtree=\"aimfl,mfl\" data-copy-service-computed-style=\"font-family: &quot;Google Sans&quot;, Arial, sans-serif; font-size: 16px; font-weight: 700; margin: 0px; text-decoration: none; border-bottom: 0px rgb(10, 10, 10);\">PAPS<\/span><!--TgQPHd||[]--><\/strong> \u3084<strong>DUES<\/strong>)\u3088\u308a\u3082\u5145\u8840\u3092\u6c17\u306b\u3059\u308b\u60a3\u8005\u3055\u3093\u306f\u591a\u3044\u3002<br \/>\n\u306e\u3067\u3001\u5145\u8840\u767a\u751f\u983b\u5ea6\u306e\u4e00\u89a7\u3092\u63b2\u8f09\u3059\u308b\u3002<\/p>\n<div style=\"overflow-x: auto;\">\n<table style=\"width: 100%; border-collapse: collapse; font-family: sans-serif; font-size: 15px; line-height: 1.5; margin: 20px 0;\">\n<thead>\n<tr style=\"background-color: #005a9c; color: white; text-align: left;\">\n<th style=\"padding: 12px; border: 1px solid #ddd;\"><\/th>\n<th style=\"padding: 12px; border: 1px solid #ddd;\">Representative Drugs<\/th>\n<th style=\"padding: 12px; border: 1px solid #ddd;\">Hyperemia Incidence (%)<\/th>\n<th style=\"padding: 12px; border: 1px solid #ddd;\">Nature of the Redness &amp; Clinical Context<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr style=\"background-color: #f9f9f9;\">\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>\u30b0\u30e9\u30ca\u30c6\u30c3\u30af<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">Ripasudil (Glanatec)<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd; font-weight: bold; color: #d9534f;\">50% \u2013 75%<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Physiological &amp; Transient:<\/strong> Caused by direct relaxation of blood vessel smooth muscle. Redness is usually mild-to-moderate, peaks 1\u20132 hours after drop instillation, and often fades within a few hours.<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>\u30ed\u30fc\u30d7\u30ec\u30c3\u30b5<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">Rhopressa<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd; font-weight: bold; color: #d9534f;\">50% \u2013 55%<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Physiological &amp; Persistent:<\/strong> Similar to pure ROCK inhibitors, but often lasts longer. It is also associated with conjunctival micro-hemorrhages (tiny red spots on the white of the eye) in about 20% of patients.<\/td>\n<\/tr>\n<tr style=\"background-color: #f9f9f9;\">\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>\u30ad\u30b5\u30e9\u30bf\u30f3\u3001\u30a8\u30a4\u30d9\u30ea\u30b9\u3001\u30bb\u30bf\u30cd\u30aa\u7cfb<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">\u2022 Latanoprost (FP)<br \/>\n\u2022 Bimatoprost (FP\/Prostamide)<br \/>\n\u2022 Omidenepag isopropyl (selective EP2 agonist)<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd; font-weight: bold;\">15% \u2013 45%<br \/>\n<span style=\"font-size: 12px; font-weight: normal; color: #666;\">(Drug dependent)<\/span><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Inflammatory\/Vasodilatory:<\/strong> FP agonists cause redness via nitric oxide release and prostaglandin-induced vasodilation.<br \/>\n\u2022 Latanoprost: ~15%<br \/>\n\u2022 Omidenepag (EP2): ~22%<br \/>\n\u2022 Bimatoprost: ~45%<\/td>\n<\/tr>\n<tr>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>\u30a2\u30a4\u30d5\u30a1\u30ac\u30f3<\/strong><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">Alphagan P (0.1%, 0.15%), Brimonidine 0.2%<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd; font-weight: bold;\">10% \u2013 25%<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Allergic\/Delayed Reaction:<\/strong> Brimonidine is an alpha-2 agonist that actually causes acute <em>vasoconstriction<\/em> (whitening the eye initially). However, with chronic use, 10\u201325% of patients develop a delayed <strong>allergic conjunctivitis<\/strong>, resulting in severe redness, itching, and follicles.<\/td>\n<\/tr>\n<tr style=\"background-color: #f9f9f9;\">\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><b>\u30a8\u30a4\u30be\u30d7\u30c8<\/b><\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\">Dorzolamide (Trusopt), Brinzolamide (Azopt)<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd; font-weight: bold; color: #5cb85c;\">1% \u2013 10%<\/td>\n<td style=\"padding: 12px; border: 1px solid #ddd;\"><strong>Very Low:<\/strong> Topical CAIs do not have significant vasodilatory properties. Redness is rare and usually due to localized chemical irritation, burning\/stinging upon instillation, or mild ocular surface dryness.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<\/div>\n<div id=\"simple-translate\" class=\"simple-translate-system-theme\">\n<div>\n<div class=\"simple-translate-button isShow\" style=\"background-image: url('chrome-extension:\/\/ibplnjkanclpjokhdolnendpplpjiace\/icons\/512.png'); height: 22px; width: 22px; top: 1316px; left: 29px;\"><\/div>\n<div class=\"simple-translate-panel \" style=\"width: 300px; height: 200px; top: 0px; left: 0px; font-size: 13px;\">\n<div class=\"simple-translate-result-wrapper\" style=\"overflow: hidden;\">\n<div class=\"simple-translate-move\" draggable=\"true\"><\/div>\n<div class=\"simple-translate-result-contents\">\n<p class=\"simple-translate-candidate\" dir=\"auto\">\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u30bb\u30bf\u30cd\u30aa\u306b\u7d9a\u304d\u3001\u65b0\u3057\u3044\u7dd1\u5185\u969c\u85ac\u304c\u767a\u58f2\u3055\u308c\u308b\u4e88\u5b9a\u3067\u3059\u3002 \u300c\u307e\u3060\u672a\u767a\u8868\u3067\u3059\u300d\u3068\u306e\u3053\u3068\u3067\u3057\u305f\u304c\u65e5\u7d4c\u30e1\u30c7\u30a3\u30ab\u30eb\u306b\u8f09\u3063\u3066\u307e\u3057\u305f\u3002 \u3088\u308b\u3068\u3001\u65b0\u85ac\u306e\u540d\u524d\u306f\u30ed\u30fc\u30d7\u30ec\u30c3\u30b5\u70b9\u773c\u6db20.02\uff05\u3067\u3001\u6210\u5206\u306f\u30cd\u30bf\u30eb\u30b9\u30b8\u30eb\u30e1\u30b7\u30eb\u9178\u5869\u3067\u3059\u3002 \u30ea\u30d0\u30b9\u30b8\u30eb\uff08 <a class=\"read-more\" href=\"https:\/\/tarumi.co.jp\/blog\/?p=5870\">READ MORE<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[13],"tags":[],"class_list":["post-5870","post","type-post","status-publish","format-standard","hentry","category-13"],"_links":{"self":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts\/5870"}],"collection":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=5870"}],"version-history":[{"count":6,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts\/5870\/revisions"}],"predecessor-version":[{"id":5877,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts\/5870\/revisions\/5877"}],"wp:attachment":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=5870"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=5870"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=5870"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}