{"id":566,"date":"2021-06-27T21:39:52","date_gmt":"2021-06-27T12:39:52","guid":{"rendered":"http:\/\/tarumi.co.jp\/blog\/?p=566"},"modified":"2021-06-27T21:39:52","modified_gmt":"2021-06-27T12:39:52","slug":"post-566","status":"publish","type":"post","link":"https:\/\/tarumi.co.jp\/blog\/?p=566","title":{"rendered":"\u300c\u7db2\u819c\u5185\u30c9\u30fc\u30d1\u30df\u30f3\u304c\u8fd1\u8996\u306e\u773c\u8ef8\u9577\u4f38\u9577\u3092\u6291\u5236\u3059\u308b\u300d\u3068\u3044\u3046\u8ad6\u6587\u3092\u8aad\u307f\u307e\u3057\u305f\u3002"},"content":{"rendered":"\n

Dopamine signaling and myopia development: What are the key challenges<\/a>\u304c\u5143\u8ad6\u6587\u3067\u3059\u3002\u3044\u308d\u3044\u308d\u306a\u8ad6\u6587\u3092\u7dcf\u89a7\u3057\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u8ad6\u6587\u3067\u3059\u3002<\/p>\n\n\n\n

\u30c9\u30fc\u30d1\u30df\u30f3<\/a>\u3068\u3044\u3046\u3068\u3001\u30d1\u30fc\u30ad\u30f3\u30bd\u30f3\u75c5<\/a>\u3067\u4f4e\u4e0b\u3057\u3001\u5e78\u798f\u611f\u3068\u95a2\u4fc2\u3059\u308b\u91cd\u8981\u306a\u8133\u5185\u30c8\u30e9\u30f3\u30b9\u30df\u30c3\u30bf\u30fc\u3068\u3044\u3046\u6587\u8108\u3067\u8a9e\u3089\u308c\u308b\u3053\u3068\u304c\u591a\u3044\u3067\u3059\u3002<\/p>\n\n\n\n

\u305d\u306e\u30c9\u30fc\u30d1\u30df\u30f3\u304c\u3001\u7db2\u819c\u5185\u306b\u304a\u3044\u3066\u306f\u773c\u8ef8\u9577\u4f38\u9577\u3092\u9632\u6b62\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u306e\u3067\u3001\u3084\u3084\u9a5a\u304d\u307e\u3057\u305f\u3002<\/p>\n\n\n\n

\u4ee5\u4e0b\u306b\u8981\u7d04\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n

Retinal DA, released in response to light, is a stop signal for homeostatic control of myopic eye growth.<\/p>

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If DA levels and\/or signaling are decreased during myopic eye growth, then increasing DA levels or DA receptor activity would be predicted to prevent myopia. <\/p>

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These observations suggest that a pharmacological approach to the treatment of myopia may be more efficacious than an environmental intervention.<\/p>

\u4ee5\u4e0a\u306e\u89b3\u5bdf\u3088\u308a\u3001\u8fd1\u8996\u6cbb\u7642\u306e\u85ac\u7269\u7684\u624b\u6cd5\u304c\u74b0\u5883\u8981\u56e0\u306e\u4ecb\u5165(\u8a33\u6ce8:\u660e\u308b\u3044\u592a\u967d\u5149\u306a\u3069\u3092\u6d74\u3073\u308b\u3053\u3068\u3092\u610f\u5473\u3057\u3066\u3044\u308b)\u3088\u308a\u3082\u6709\u7528\u304b\u3082\u3057\u308c\u306a\u3044\u3068\u793a\u5506\u3055\u308c\u308b\u3002<\/p><\/blockquote>\n\n\n\n

In general, these studies show that activation of D2-like receptors by subconjunctival or intravitreal agonist injection mimics the protective effect of periods of unobstructed vision on FDM.<\/p>

\u4e00\u822c\u7684\u306b\u8a00\u3063\u3066\u3001\u3053\u308c\u3089\u306e\u7814\u7a76\u304b\u3089\u3001\u30c9\u30d1\u30df\u30f32\u30ec\u30bb\u30d7\u30bf\u30fc\u3092\u7d50\u819c\u4e0b\u3042\u308b\u3044\u306f\u785d\u5b50\u4f53\u5185\u306b\u30c9\u30d1\u30df\u30f3\u4f5c\u52d5\u85ac\u3092\u6ce8\u5165\u3059\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u3001FDM(form deprivation myopia,\u5f62\u614b\u899a\u906e\u65ad\u8fd1\u8996,\u8996\u6027\u523a\u6fc0\u906e\u65ad\u8fd1\u8996)\u306e\u975e\u906e\u853d\u773c\u3068\u540c\u69d8\u306e\u9632\u5fa1\u52b9\u679c\u304c\u3048\u3089\u308c\u308b\u3053\u3068\u3092\u793a\u3057\u3066\u3044\u308b\u3002<\/p><\/blockquote>\n\n\n\n

From a therapeutic perspective, local administration of apomorphine<\/a> (APO) and DA by eye drops may achieve therapeutic effects on myopia, with reduced systemic side effects. <\/p>

\u6cbb\u7642\u7684\u89b3\u70b9\u304b\u3089\u3059\u308b\u3068\u3001\u30a2\u30dd\u30e2\u30eb\u30d5\u30a3\u30f3\u3084\u30c9\u30d1\u30df\u30f3\u306e\u70b9\u773c\u306b\u3088\u3063\u3066\u3001\u5168\u8eab\u526f\u4f5c\u7528\u3092\u6291\u3048\u3064\u3064\u3001\u8fd1\u8996\u6cbb\u7642\u52b9\u679c\u3092\u4e0a\u3052\u308b\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/p><\/blockquote>\n\n\n\n

Furthermore, bi-phasic effects have been reported for APO and the D2-like agonist quinpirole<\/a> on control of myopia: high doses of APO inhibit FDM, while low doses promote FDM in guinea pigs (Jiang et al., 2014b<\/a>); in contrast, quinpirole inhibits myopia at low doses and promotes myopia at high doses in C57\/BL6 mice (Zhou, unpublished data)<\/p>

\u3055\u3089\u306b\u8a00\u3046\u3068\u3001\u30a2\u30dd\u30e2\u30eb\u30d5\u30a3\u30f3\u3084D2\u95a2\u9023\u4f5c\u52d5\u85ac\u30af\u30a4\u30f3\u30d4\u30ed\u30fc\u30eb\u306e\u8fd1\u8996\u306b\u5bfe\u3059\u308b\u5f71\u97ff\u306f\u4e8c\u76f8\u6027\u304c\u3042\u308b\u3002\u9ad8\u5bb9\u91cf\u30a2\u30dd\u30e2\u30eb\u30d5\u30a3\u30f3\u306f\u30e2\u30eb\u30e2\u30c3\u30c8\u306b\u304a\u3051\u308b\u8996\u6027\u523a\u6fc0\u906e\u65ad\u8fd1\u8996\u3092\u6291\u5236\u3059\u308b\u304c\u3001\u4f4e\u7528\u91cf\u3060\u3068\u9006\u306b\u4fc3\u9032\u3059\u308b\u3002\u4e00\u65b9\u3067\u3001\u30af\u30a4\u30f3\u30d4\u30ed\u30fc\u30eb\u306f\u30de\u30a6\u30b9\u306e\u8fd1\u8996\u3092\u4f4e\u7528\u91cf\u3067\u306f\u6291\u5236\u3059\u308b\u304c\u3001\u9ad8\u5bb9\u91cf\u3067\u306f\u4fc3\u9032\u3059\u308b\u3002<\/p><\/blockquote>\n\n\n\n

\u576a\u4e95\u5148\u751f\u304c\u63d0\u5531\u3059\u308b\u300c\u30d0\u30a4\u30aa\u30ec\u30c3\u30c8\u30e9\u30a4\u30c8\u304c\u8fd1\u8996\u6291\u5236\u306b\u6709\u52b9\u300d\u3068\u3044\u3046\u306e\u3082\u3001\u7db2\u819c\u5185\u30c9\u30d1\u30df\u30f3\u30ec\u30d9\u30eb\u3092\u4e0a\u6607\u3055\u305b\u308b\u3053\u3068\u306b\u3088\u3063\u3066\u52b9\u3044\u3066\u308b\u306e\u304b\u3082\u3057\u308c\u306a\u3044\u3002<\/p>\n\n\n\n

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Dopamine signaling and myopia development: What are the key challenges\u304c\u5143\u8ad6\u6587\u3067\u3059\u3002\u3044\u308d\u3044\u308d\u306a\u8ad6\u6587\u3092\u7dcf\u89a7\u3057\u305f\u30e1\u30bf\u30a2\u30ca\u30ea\u30b7\u30b9\u8ad6\u6587\u3067\u3059\u3002 \u30c9\u30fc\u30d1\u30df\u30f3\u3068\u3044\u3046 READ MORE<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-566","post","type-post","status-publish","format-standard","hentry","category-19"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts\/566"}],"collection":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=566"}],"version-history":[{"count":0,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts\/566\/revisions"}],"wp:attachment":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=566"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=566"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=566"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}