{"id":3824,"date":"2023-11-12T15:46:53","date_gmt":"2023-11-12T06:46:53","guid":{"rendered":"http:\/\/tarumi.co.jp\/blog\/?p=3824"},"modified":"2024-08-27T02:57:29","modified_gmt":"2024-08-27T02:57:29","slug":"post-3824","status":"publish","type":"post","link":"https:\/\/tarumi.co.jp\/blog\/?p=3824","title":{"rendered":"\u65b0\u3057\u3044\u8fd1\u8996\u6cbb\u7642\u70b9\u773c\u85ac(\u6176\u5fdc\u5927\u5b66\u3068\u30ed\u30fc\u30c8\u88fd\u85ac\u306e\u5171\u540c\u7814\u7a76)"},"content":{"rendered":"\r\n

\u65e5\u7d4c\u65b0\u805e\u306b\u76ee\u85ac\u3067\u8fd1\u8996\u306e\u9032\u884c\u6291\u5236<\/a>\u3068\u3044\u3046\u8a18\u4e8b\u304c\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002
\u30a2\u30c8\u30ed\u30d4\u30f3<\/a>\u3084\u30af\u30ed\u30bb\u30c1\u30f3<\/a>\u3068\u306f\u7570\u306a\u308b\u6a5f\u5e8f\u306e\u65b0\u85ac\u3092\u3001\u576a\u7530\u5148\u751f\u3068\u30ed\u30fc\u30c8\u88fd\u85ac\u304c\u5171\u540c\u7814\u7a76<\/strong>\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u5185\u5bb9\u3002<\/p>\r\n\r\n\r\n\r\n

\u30ed\u30fc\u30c8\u88fd\u85ac\u306b\u554f\u3044\u5408\u308f\u305b\u3001\u4e0b\u8a18\u306eScleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes<\/a>\u3092\u6559\u3048\u3066\u3044\u305f\u3060\u304d\u307e\u3057\u305f\u3002<\/p>\r\n\r\n\r\n\r\n

\r\n\r\n\r\n\r\n

\u30de\u30a6\u30b9\u5b9f\u9a13\u3067<\/p>\r\n\r\n\r\n\r\n

endoplasmic reticulum(ER) stress(\u203b)<\/sup>\u2191\u2192\u00a0PERK and ATF6\u7cfb\u306e\u6d3b\u6027\u2191\u2192\u773c\u8ef8\u9577\u2191
\u3000\u21e9
4-phenylbutyric acid (4-PBA)\u6295\u4e0e\u2192endoplasmic reticulum(ER) stress\u2193\u2192\u773c\u8ef8\u9577\u2193
\u3000\u21e9
4-phenylbutyric acid (4-PBA)\u306f\u3001\u8fd1\u8996\u6cbb\u7642\u306b\u6709\u671b\u3067\u3042\u308b\u3002<\/p>\r\n\r\n\r\n\r\n

\u3068\u3001\u3044\u3046\u306e\u304c2022\/10\u767a\u8868\u306e\u8ad6\u6587\u9aa8\u5b50\u3067\u3042\u308b\u3002<\/p>\r\n\r\n\r\n\r\n

\u3000<\/p>\r\n\r\n\r\n\r\n

\u3053\u306e\u5ea6\u3001\u56fd\u5185\u7b2cI\u76f8\u81e8\u5e8a\u8a66\u9a13\uff08\u4ee5\u4e0b\u3001\u300c\u672c\u8a66\u9a13\u300d\uff09\u306b\u5411\u3051\u3066\u306e\u6e96\u5099\u304c\u6574\u3044\u307e\u3057\u305f\u306e\u3067\u3001\u672c\u8a66\u9a13\u3092\u958b\u59cb\u3044\u305f\u3057\u307e\u3059\u3002<\/p><\/blockquote>\r\n\r\n\r\n\r\n

\u3068\u3001\u3044\u3046\u306e\u304c2023\/11\u767a\u8868\u306e\u8a18\u4e8b\u3067\u3042\u308b\u3002<\/p>\r\n\r\n\r\n\r\n

\u3000<\/p>\r\n\r\n\r\n\r\n

\u576a\u7530\u5148\u751f\u306f\u30d9\u30f3\u30c1\u30e3\u30fc\u7d4c\u55b6<\/a>\u3055\u308c\u3066\u3044\u308b\u3060\u3051\u3042\u3063\u3066\u3001\u52d5\u304d\u304c\u901f\u3044\u306a\u3068\u611f\u5fc3\u3059\u308b\u3002<\/p>\r\n\r\n\r\n\r\n

\u305f\u3060\u3001violet light\u3068\u3044\u3044\u3001\u610f\u5916\u3068\u5b9f\u7528\u5316\u306b\u6642\u9593\u304b\u304b\u308b\u611f\u3058\u3067\u3042\u308a\u307e\u3057\u3087\u3046\u304b\u3002<\/p>\r\n\r\n\r\n\r\n

\r\n\r\n\r\n\r\n

(\u203b)\u5c0f\u80de\u4f53\u306e\u4e2d\u306b\u3001\u6298\u308a\u7573\u307f\u4e0d\u5168\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3057\u305f\u3068\u304d\u306b\u8a8d\u3081\u3089\u308c\u308b\u72b6\u614b\u306e\u3053\u3068\u3092endoplasmic reticulum(ER) stress\u3068\u3044\u3044\u30014-phenylbutyric acid (4-PBA)\u306f\u3001\u3053\u306e\u6298\u308a\u7573\u307f\u4e0d\u5168\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u6b63\u3057\u304f\u6298\u308a\u305f\u305f\u3080\u306e\u3092\u624b\u52a9\u3051\u3059\u308bchaperone(\u4ecb\u6dfb\u3048\u4eba)\u3068\u3057\u3066\u50cd\u304f\u3089\u3057\u3044\ud83d\udca6<\/p>\r\n\r\n\r\n\r\n

\"\"
\u5de6\u306f\u6b63\u5e38\u773c\u306e\u5f37\u819c\u7dda\u7dad\u82bd\u7d30\u80de\u3001\u53f3\u306f\u6298\u308a\u7573\u307f\u4e0d\u5168\u306e\u30bf\u30f3\u30d1\u30af\u8cea\u304c\u84c4\u7a4d\u3057\u305f\u8fd1\u8996\u773c\u306e\u5f37\u819c\u7dda\u7dad\u82bd\u7d30\u80de<\/sub><\/figcaption><\/figure>\r\n\r\n\r\n\r\n

<\/p>\r\n","protected":false},"excerpt":{"rendered":"

\u65e5\u7d4c\u65b0\u805e\u306b\u76ee\u85ac\u3067\u8fd1\u8996\u306e\u9032\u884c\u6291\u5236\u3068\u3044\u3046\u8a18\u4e8b\u304c\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u30a2\u30c8\u30ed\u30d4\u30f3\u3084\u30af\u30ed\u30bb\u30c1\u30f3\u3068\u306f\u7570\u306a\u308b\u6a5f\u5e8f\u306e\u65b0\u85ac\u3092\u3001\u576a\u7530\u5148\u751f\u3068\u30ed\u30fc\u30c8\u88fd\u85ac\u304c\u5171\u540c\u7814\u7a76\u3057\u3066\u3044\u308b\u3068\u3044\u3046\u5185\u5bb9\u3002 \u30ed\u30fc\u30c8\u88fd\u85ac\u306b\u554f\u3044\u5408\u308f\u305b\u3001\u4e0b\u8a18\u306eScleral PERK and READ MORE<\/a><\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[19],"tags":[],"class_list":["post-3824","post","type-post","status-publish","format-standard","hentry","category-19"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts\/3824"}],"collection":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=3824"}],"version-history":[{"count":3,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts\/3824\/revisions"}],"predecessor-version":[{"id":4478,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=\/wp\/v2\/posts\/3824\/revisions\/4478"}],"wp:attachment":[{"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=3824"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=3824"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tarumi.co.jp\/blog\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=3824"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}